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Van A. Doze, PhD
- Ph.D., Molecular and Cellular Physiology, Stanford University
- Research Fellow, Neurophysiology, Stanford University
- Research Fellow, Neuropharmacology, Stanford University
Our laboratory uses a combination of electrophysiological and imaging techniques to study the modulation of neuronal activity ("neuromodulation") in the mammalian central nervous system. Current research directions include:
- Function and modulation qf interneurons. Inhibitory GABAergic interneurons are being characterized according to their location, synaptic physiology, morphology and sensitivity to various neuromodulators such as norepinephrine. This research may lead to a greater understanding of the role played by different types of interneurons in regulating neuronal activity and lead to novel therapeutic strategies for treating epilepsy.
- Alterations in calecholaminergic transmission. The presynaptic mechanisms underlying dopamine release and the modulation of this release by various factors (e.g., neurotoxins) are being studied. The information derived from this research may provide clues into the prevention of Parkinson's disease.
- Role of glial cells in neurodegeneration. Microglia are being characterized by their electrophysiological properties in normal and pathologic states. This research may give important insights into the mechanisms underlying Alzheimer's disease· Electrophysiology techniques employed in the laboratory include extracellular field potential, intracellular and whole-cell recordings, as well as infrared video microscopy to record from directly visualized cells.
neurodegeneration, alzheimer's disease, epilepsy, parkinson's disease, neuropharmacology, acetylcholine, dopamine, GABA, glutamate, norepinephrine, opiates, neurophysiology, ion channel, neurotransmitter release, synaptic transmission, transporter currents, neuroanatomy, brain slices, hippocampus, locus coeruleus, substantia nigra, catecholaminergic neurons, glial cells, interneurons, electrophysiology, intracellular recording, patch-clamp, infrared imaging
- Doze VA, Papay RS, Goldenstein BL, Gupta MK, Collette KM, Nelson BW, Lyons MJ, Davis BA, Luger EJ, Wood SG, Haselton JR, Simpson PC, Perez DM. Long-term α1A-adrenergic receptor stimulation improves synaptic plasticity, cognitive function, mood, and longevity. Mol Pharmacol. 2011 Oct;80(4):747-58.
- Perez DM, Doze VA (2011) Cardiac and neuroprotection regulated by α1-adrenergic receptor subtypes. J Recept Signal Transduct Res 31, 98-110.
- Hillman KL, Lei S, *Doze VA, *Porter JE (2009) Alpha-1A adrenergic activation increases inhibitory tone in CA1 hippocampus. Epilepsy Res 84, 97-109.
- Goldenstein BL, Nelson BW, Xu K, Luger EJ, Pribula JA, Wald JM, O’Shea LA, Weinshenker D, Charbeneau RA, Huang X, Neubig RR, Doze VA (2009) Regulator of G protein signaling suppression of G-alpha-o protein-mediated alpha-2A adrenergic receptor inhibition of mouse hippocampal CA3 epileptiform activity. Mol Pharmacol 75, 1222-1230.
- Xiao Z, Deng PY, Rojanathammanee L, Yang C, Grisanti L, Permpoonputtana K, Weinshenker D, Doze VA, Porter JE, Lei S (2009) Noradrenergic depression of neuronal excitability in the entorhinal cortex via activation of TREK-2 K+ channels. J Biol Chem 284, 10980-10991.
- Gupta MK, Papay RS, Jurgens CW, Gaivin RJ, Shi T, Doze VA, Perez DM (2009) alpha1-Adrenergic receptors regulate neurogenesis and gliogenesis. Mol Pharmacol 76, 314-326 (cover issue).
- Doze VA, Handel EM, Jensen KA, Darsie B, Luger EJ, Haselton JR, Talbot JN, Rorabaugh BR (2009) alpha1A- and alpha1B- adrenergic receptors differentially modulate antidepressant-like behavior in the mouse. Brain Res 1285, 148-157.
- Carroll RG, Matyas ML, Atwater AE, Doze V, Faircloth R, Finkenstadt P, Goodman B, Henriksen EJ, Horwitz B, Looft-Wilson R, Madsen B, Mody J, Pelaez N, Pressley TA (2007) APS undergraduate brainstorming summit report. Adv Physiol Educ 31, 380-386.
- Hillman KL, *Doze VA, *Porter JE (2007) Alpha1A-adrenergic receptors are functionally expressed by a subpopulation of CA1 interneurons in rat hippocampus. J Pharmacol Exp Ther 321, 1062-1068.
- Jurgens CWD, Hammad HM, Lichter JA, Boese SJ, Nelson BW, Goldenstein BL, Davis KL, Xu K, Hillman KL, Porter JE, Doze VA (2007) alpha2A Adrenergic receptor activation inhibits epileptiform activity in the rat hippocampal CA3 region. Mol Pharmacol 71, 1572-1581.
- Papay R, Gaivin R, Jha A, McCune DF, McGraft JC, Rodrigo MC, Simpson PC, Doze VA, Perez DM (2006) Localization of the mouse alpha1A-adrenergic receptor in the brain: alpha1A-AR is expressed in neurons, GABAergic interneurons and NG2 oligodendrocyte progenitors. J Comp Neurol 497, 209-222.
- Hillman KL, Knudson CA, Carr PA, *Doze VA, *Porter JE (2005) Adrenergic receptor characterization of CA1 hippocampal neurons using real time single cell RT-PCR. Brain Res Mol Brain Res 139, 267-276.
- Jurgens CW, Rau KE, Knudson CA, King JD, Carr PA, Porter JE, Doze VA (2005) β1 Adrenergic receptor-mediated enhancement of hippocampal CA3 network activity. J Pharmacol Exp Ther 314, 552-560.
- Hillman KL, *Doze VA, *Porter JE (2005) Functional characterization of the β-AR subtypes expressed by CA1 pyramidal cells in the rat hippocampus. J Pharmacol Exp Ther 314, 561-567.
- Jurgens CW, Boese SJ, King JD, Pyle SJ, Porter JE, Doze VA (2005) Adrenergic receptor modulation of hippocampal CA3 network activity. Epilepsy Res 66, 117-128.
- Hintz KK, Norby FL, Duan J, Cinnamon MA, Doze VA, Ren J (2002) Comparison of cardiac excitation-contraction coupling in isolated ventricular myocytes between rat and mouse. Comparative Biochemistry and Physiology Part A Mol Integr Physiol 133, 191-198.
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