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Epigenomics of Development and Disease


Postdoc positions available!

Postdoctoral positions are available immediately to work on exciting NIH- funded projects in the field of Epigenomics to be carried out in the newly formed Center Of Biomedical Research Excellence at the University of North Dakota. Highly motivated individuals with an interest in cell biology, epigenetics and epigenomics are encouraged to apply. Candidates must be able to work well in a team environment and be willing to participate in training of graduate and undergraduate students. The Epigenomics group offers a highly supportive and collaborative environment to perform state-of-the-art research. Minorities and women are encouraged to apply. Interested candidates should send a copy of their CV and 3 letters of reference. Grand Forks is a very affordable and family-friendly city with excellent schools, parks and abundant year-round outdoor recreational activities. UND determines employment eligibility through the E-Verify system. University of North Dakota is an Affirmative Action/Equal Opportunity Employer. 

1) A Post Doctoral position is available immediately to study the role of chromatin and other epigenetic processes in a phenomenon called EMT (Epithelial to Mesenchymal Transition), which leads to cancer metastasis. A multidisciplinary strategy is being used in this study, which includes biochemical, molecular biological, and genome-wide techniques and, in the future, in vivo functional studies involving animal models. Candidates are also expected to interact with faculty, staff, and students within a larger group (approximately 20 laboratories) of researchers at UND studying the Epigenomics of Development and Disease. Candidates with considerable experience in Molecular biology, Cell Biology, Biochemistry or related fields are encouraged to apply. Experience with any of the following will be an advantage: Chromatin Biology, non-coding RNAs, DNA methylation, -omics platforms, FACS-based assays, microscopy, gene expression profiling (RNA-Seq and microarrays), next-generation sequencing, familiarity working with knockout and transgenic mouse models, mammalian cell culture models including embryonic and adult stem cells, and bioinformatics experience.


Please APPLY HERE for the relevant position(s).

History

Our epigenetics research working group has been meeting regularly since 2010 and has grown to include approximately twenty laboratories from three departments in the School of Medicine and Health Sciences, as well as talented scientists from the College of Nursing, the College of Arts and Sciences, and the USDA Grand Forks Human Nutrition Research Center. Most of the epigenetics group members are early career investigators or those with established research programs in other fields whose research has led them to the exciting area of epigenetics/epigenomics research. In addition to the five junior investigators who would receive project support through our pending COBRE: Center of Biomedical Research Excellence in the Epigenomics of Development and Disease, this working group includes several well-established federally-funded investigators with expertise in cancer, neurodegenerative diseases, auto-immune disorders, and aging. The more established members of the group will serve as collaborators, mentors, and on the Internal Advisory Board to support the Center generally, and more specifically to assist the junior investigators with all aspects of our mission.

 

Research Interests

Featured UND Investigator

Dr. Sergei Nechaev

Nechaev photo

Sergei Nechaev, PhD was appointed as an Assistant Professor in the Department of Anatomy and Cell Biology in January 2012. UNDSMHS recruited Dr. Nechaev from  the National Institute of Environmental Health Sciences at NIH in North Carolina, where he was a postdoctoral researcher for five years. Dr. Nechaev earned his doctorate from the State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russia.

Dr. Nechaev in the Project Leader for Project 1 of our proposed COBRE Center investigating the roles of RNA polymerase II pausing as a dynamic epigenetic mark during neural stem cell differentiation.

His pioneering work on RNA polymerase II pausing has resulted in a 2010 Science publication: Global Analysis of Short RNAs Reveals Widespread Promoter-Proximal Stalling and Arrest of Pol II in Drosophila.

In his spare time, Sergei enjoys mushroom hunting and cross country skiing, depending on the season.

 

Announcements

  • Congratulations to Drs. Roxanne Vaughan, Joyce Ohm, Sergei Nechaev, Lucia Carvelli, Cindy Anderson and Archana Dhasarathy for their $10.5 million COBRE award!
  • Congratulations to Dr. Joyce Ohm for receiving her first NIH R01 grant for a total of $1,552,500; titled ""Environmental Toxins and Stem Cell Epigenetic Remodeling". Other UND investigators who will collaborate with Dr. Ohm on this grant are Drs. Kurt Zhang, Brij Singh and John Watt.
  • Congratulations to Drs. Sergei Nechaev and Archana Dhasarathy for successfully competing for a ND EpSCOR 2012 Equipment grant to purchase a state of the art Covaris Sonicator. This grant entitled Epigenetic Mechanisms of Cell Differentiation was for a total of $46,600 to purchase a Covaris S220 Adaptive Focused Acoustics Ultrasonicator. This instrument will be extraordinarily useful for anyone in the epigenetics working group looking to fragment RNA, DNA, or crosslinked chromatin prior to ChIP, next generation sequencing, or other downstream applications. For training and instrument access, please contact Dr. Nechaev. 

 

Epigenetics Links

Epigenetics COBRE I Sharepoint site (password protected, contact Joyce if you need access)

NIH Epigenomics Roadmap Project

The NIH R01 toolkit has useful information and additional links

NIEHS Research Programs

Genecards

UCSC Genome Browser

Epigenie - Epigenetics news and resources

Database for Annotation, Visualization and Integrated Discovery (DAVID) Bioinformatics Resources 6.7 - Useful for annotating genome data and pathway analysis

Jim Bone's Chromatin Page lists chromatin researchers, has announcements of meetings and postdoc positions.

Histone antibodies that are good to use:

Methprimer: design primers for bisulfite sequencing or MSP

Bisulfite sequencing Data Presentation and Compilation : A useful website to analyze and interpret your bisulfite sequencing data.

The histone modifications App: easily check up on roles of different histone modifications