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Jonathan D. Geiger, PhD
- PhD in Pharmacology and Physiology, The University of North Dakota; 1979–1982
- MS in Pharmacology and Physiology, The University of North Dakota; 1973–1975
- BS in Chemistry, Windham College; 1970–1973
Born and raised in Syracuse, New York, Dr. Geiger came to Winnipeg, Manitoba, Canada in 1982 to conduct post-doctoral training with Dr. Frank LaBella in the Department of Pharmacology and Therapeutics. In 1984 he accepted an appointment as Assistant Professor in the Department of Pharmacology and Therapeutics in the Faculty of Medicine at the University of Manitoba. In 1989, he was promoted to Associate Professor and in 1994 he was promoted to full Professor. In 1999, he founded and until 2003 was the Director of the Division of Neurovirology and Neurodegenerative Disorders at the St. Boniface Hospital Research Centre. In 2003, he was recruited back to UND as Chair of the Department of Pharmacology, Physiology and Therapeutics and PI on a neuroscience COBRE grant. He has consistently held multiple federal operating grants simultaneously throughout his career, and received highly prestigius Scholarship and Scientist awards from the Canadian Institutes of Health Research (CIHR). He is currently funded by grants from the NIH. The main focus of his research continues to be on brain energy metabolism in general and purines in particular, regulation of levels of intracellular calcium with emphasis on intracellular pools of calciu, and the control of neuronal cell life and death.
Currently, his laboratory has the following research interests: (1) The ability of calcium in endosomes/lysosomes to influence capacitative influx of calcium and calcium-induced calcium release from ER and mitochondria; (2) The role of endosome/lysosome dysfunction in animal models of Alzheimer's disease, HIV-1 associated dementia and inclusion body myositis; (3) The ability of caffeine to block adenosine receptors and protect against blood brain barrier dysfunction in animal models of Alzheimer's and Parkinson's disease; and (4) The role of brain energy metabolism (with particular emphasis on adenosine and ATP) in the pathogenesis of epilepsy and neurodegenerative diseases. He has published over 140 manuscripts and has delivered over 100 invited talks worldwide. He continues to serve on multiple grant review committees including those for the NIH and the CIHR.
Ongoing Research Support:
COBRE Center for Neurodegenerative Disorder Research.
Principal Investigator: Dr. Jonathan Geiger
Agency: National Institutes of Health
The long term goal of this project is to support our neurodegenerative disease research group's administrative core, pilot grant program, and our mass spectrometry and imaging cores. Our COBRE group continues to focus on determining mechanisms responsible for the pathogenesis of and identifying possible therapeutic interventions against neurodegenerative disorders.
Neuronal Endolysosome Involvement in HIV-1
Tat-induced Amyloid Beta Accumulation.
Co-Principal Investigators: Dr. Jonathan Geiger and
Xuesong Chen, MD
Agency: National Institute on Aging
The major goals of this project are to test the hypothesis that Tat increases intraneuronal Aβ production by promoting APP internalization and elevating endolysosome pH.
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Role of Adenosine in the Protective Effects of Ketogenic Diet
Principal Investigator: Dr. Susan Masino
Co-Investigators: Jonathan Geiger and Dr. Detlev Boison
The long term goal of this project is to test the hypothesis that the anti-seizure and and neuroprotective effects of ketogenic diet are due to increased levels and actions of adenosine.
- Bhatt, D.P., Chen, X., Geiger, J.D., and Rosenberger, T.A. (2012) A sensitive HPLC-based method to quantify adenine nucleotides in primary astrocyte cell cultures. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 889-890:110-5.
- Masino, S.A., Ruskin, D.N., Geiger, J.D., and Boison, D. (2011) Purines and Neuronal Excitability: Links to the Ketogenic Diet. Epilepsy Res. [Epub ahead of print].
- Masino, S.A., Li, T., Theofilas, P., Fredholm, B.B., Geiger, J.D., Aronnica, E. and Boison, D. (2011) A Ketogenic Diet Suppresses Seizures in Mice Through Adenosine A1 Receptors. Journal of Clinical Investigation 121: 2679-2683.
- Masino, S.A., Li, T., Theofilas, P., Fredholm, B.B., Geiger, J.D., Aronnica, E. and Boison, D. (2011) A Ketogenic Diet Suppressess Seizures in Mice Through Adenosine A1 Receptors. Journal of Clinical Investigation [Epub ahead of print].
- Ruskin, D.N., Ross, J.L., Kawamura Jr., M., Ruiz, T.L., Geiger, J.D. and Masino, S.A. (2011) A Ketogenic Diet Delays Weight Loss and Does Not Impair Working Memory or Motor Function in the R6/2 J1 Mouse Model of Huntington's Disease. Physiol. and Behav. 103: 501–507.
- Boison, D., Masino, S.A. and J.D. Geiger (2011) Homeostatic bioenergetics network regulation—a novel concept to avoid pharmacoresistance in epilepsy. Expert Opinon on Drug Discovery 6: 713–724.
- Masino, S.A. Kawamura, M. Ruskin, D.N., Gawryluk, J., Chen, X., and J.D. Geiger. (2010) Purines and the Anti-Epileptic Actions of Ketogenic Diets. Special Issue on "Purinergic Signaling in Epilepsy", Open Neuroscience Journal (in press).
- Deng, P.Y., Jha, A., Ramonet, D., Matsui, T., Leitges, M., Shin, H-S., Porter, J., Geiger, J.D. and S. Lei (2010). Cholecystokinin Facilitates Glutamate Release by Increasing the Number of Readily Releasable Vesicles and Releasing Probability. J. Neurosci. 30:5136–5148.
- Ghribi, O., Prasanthi, J.R., Dasari, B., Larson, T., Marwarha, G., Chen, X. and J.D. Geiger. (2010) Caffeine Protects Against Oxidative Stress and Alzheimer's Disease-Like Pathology in Rabbit Hippocampus Induced by Cholesterol-Enriched Diet. Free Radical Biology and Medicine 49: 1212–1220.
- Chen, X., Ghribi, O. and J.D. Geiger. (2010) Caffeine Protects Against Disruptions of the Blood-Brain Barrier in Animal Models of Alzheimer's and Parkinson's Disease. J. Alz. Disease 20: S127–141.
- Chen, X., Lan, X., Roche, I., Liu, R., and J.D. Geiger. (2008) Caffeine Protects Against MPTP-Induced Blood Brain Barrier Dysfunction in Mouse Striatum. J. Neurochem. 107: 1147–1157.
- Chen, X., Ghribi, O. and J.D. Geiger. (2008) Rabbits Fed Cholesterol-Enriched Diets Exhibit in Skeletal Muscle Many of the Pathological Features of Inclusion Body Myositis. Amer. J. Physiology 294: 829–835.
- Chen, X., Gawryluk, J.W., Wagener, J.F., Ghribi, O., and J.D. Geiger. (2008) Caffeine Blocks Disruption of Blood Brain Barrier in a Rabbit Model of Alzheimer's Disease. J. Neuroinflammation 5: 12.
- Masino, S.A. and J.D. Geiger. (2008) Are Purines Mediators of the Anticonvulsant/Neuroprotective Effects of Ketogenic Diets? Trends in Neurosciences 31(6): 273–278.
- Chen, J-F., Ascherio, A., Sonsalla, P., Pedata, F., Melani, A., Domenici, M.R., Popolli, P., Geiger, J.D., Lopes, L.V., and de mendonca, A. (2007)
Adenosine A2A Receptors and Brain Injury: Broad Spectrum of Neuroproection, Multi-Faced Actions and "Fine-Tuning" Modulation. Prog. Neurobiol. 2007, 83: 310–331. (All authors contributed equally to this review.)
- Zhang, S., Zhang, Z., Sandhu, G., Ma, X., Yang, X., Geiger, J.D. and J. Kong. (2007) Evidence of Oxidative Stress-Induced BNIP3 Expression in Amyloid Beta Neurotoxicity. Brain Research 1138: 221–230.
- Shepel PN, Ramonet D, Stevens P, Geiger JD. Purine level regulation
during energy depletion associated with graded excitatory stimulation in brain. Neurol Res. (2005) Mar;27(2):139-48.
- Goel, D., J.D. Geiger, D. Kreillaars, J. Shan, (CV Technologies) and G. Pierce. “Doping control urinalysis of a ginseng extract, cold-Fx, in athletes”. International Journal of Sport Nutrition and Exercise Metabolism 14 (2004) 473-480.
- Fotheringham, J.A., M.B. Mayne, J.A. Grant, and J.D. Geiger. “Activation of adenosine receptors inhibits tumor necrosis factor-a release by decreasing TNF-a mRNA stability and p38 activity”. European Journal of Pharmacology 497 (2004) 87-95.
- Fotheringham, J., M. Mayne, C. Holden, A. Nath, and J.D. Geiger. “Adenosine receptors control HIV-1 Tat-induced inflammatory responses through protein phosphatase”. Virology 327 (2004) 186-195.
- Song, L., A. Nath, J.D. Geiger, A. Moore, and S. Hochman. Human Immunodeficiency Virus Type 1 Tat Protein Directly Activates Neuronal N-Methyl-D-Aspartate Receptors at an Allosteric Zinc-Sensitive Site. J. Neurovirol. 2003, 9(3); 399-403.
- Turchan, J., C.B. Pocernich, C.Gairola, A. Chauhan, B. Schifitto, D.A. Butterfield, S. Buch, O. Narayan, A. Sinai, J.D. Geiger, J.R. Berger, H. Elford, and A. Nath. Oxidative Stress in HIV Demented Patients and Protection Ex-vivo with Novel Antioxidants. Neurology 2003, 60(2); 307-314.
- Dakshinamurti, D., S.K. Sharma and J. D. Geiger . Neuroprotective actions of pyridoxine. Biochim. Biophys. Acta. 2003, 1647 (1-2); 225-229.
- M. Mackiewicz, E.V. Nikonova, J.E. Zimmerman, R.J. Galante, L. Zhang, J.D. Geiger and A.I. Pack. Enzymes of Adenosine Metabolism in Rat Brain: Diurnal Rhythm and Effect of Sleep Deprivation. J. Neurochem. 2003, 85(2); 348-357.
- Shepel, N., C.P. Holden, J.D. Geiger. Ryanodine receptor modulation by diadenosine polyphosphates in synaptosomal and microsomal preparations of rat brain. Eur. J. Pharmacol. 2003, 467(1-3); 67-71.
- Bouchard, R., R. Pattarini and J.D. Geiger. Presence and Functional Significance of Presynaptic Ryanodine Receptors. Prog. in Neurobiol. 2003, 69(6); 391-418.
- Othman, T., C.J.D. Sinclair, N. Haughey, J.D. Geiger and F.E. Parkinson. Ethanol alters glutamate but not adenosine uptake in rat astrocytes: Evidence for protein kinase C involvement. Neurochem. Res. 2002, 27(3); 289-296.
- Kong, J., C.P. Holden , P.N. Shepel, B.F. Singer, M. Mackiewicz , A.I. Pack and J.D. Geiger. Brain glycogen decreases with increased periods of wakefulness - implications for homeostatic drive to sleep. J. Neuroscience. J. Neurosci. 2002, 22(13); 5581-5587.
- Bouchard, R., A.R. Weber and J. D. Geiger. Informed Decision Making on Sympathomimetic Use in Sport and Health. Clinical Journal of Sports Medicine. 2002, 12(4); 209-224.
- Parkinson, F., C. Sinclair, T. Othman, N. Haughey, J.D. Geiger. Differences between rat primary cortical neurons and astrocytes in purine release evoked by ischemic conditions. Neuropharmacol. 2002, 43(5); 836-846.
- Geiger, J.D. Adverse Events Associated with Supplements Containing Ephedra Alkaloids. Clinical Journal Sport Medicine. 2002, 12(4); 263.
- Mayne, M., H.J. Yan, J. Fotheringham, C. Power, M.R. Del Bigio, J. Peeling and J.D. Geiger. Adenosine A2A Receptor Activation Reduces Pro-Inflammatory Events and Decreases Cell Death Following Intracerebral Hemorrhage. Ann. Neurol. 2001, 49; 727-735.
- Glazner, G.W., S. Camoandola, J.D. Geiger and M.P. Mattson. Endoplasmic Reticulum D-myo-Inositol1,4,5-Trisphosphate Sensitive Stores Regulate Nuclear Factor-KappaB Binding Activity in a Calcium Independent Manner. J. Biol. Chem. 2001, 276; 22461-22467.
- Holden, C.P., A. Nath and J.D. Geiger. Diadenosine Pentaphosphate Increases Levels of Intracellular Calcium in Astrocytes by a Mechanism Involving Release from Caffeine/Ryanodine- and IP3 Sensitive Stores. J. Neurosci. Res. 2000, 59; 276-282.
- Mattson, M.P, F.M. LaFaerla, S.L. Chan, M.A. Lessring, P.N. Shepel, and J.D. Geiger. Calcium Signalling in the ER: Its Role in Neuronal Plasticity and Neurodegenerative Disorders. Trends in Neurological Sciences 2000, 23; 222-229.
- Nath, A., N. Haughey, M. Jones, C. Anderson, J.E. Bell and J.D. Geiger. Synergistic Increases in Neurotoxicity by the HIV-1 Proteins Tat and gp120 - Neuroprotection by Memantine. Ann. Neurol. 2000, 47; 186-194.
- Sinclair, C.J.D., P.N. Shepel, J.D. Geiger and F.E. Parkinson. Stimulation of Nucleoside Efflux and Inhibition of Adenosine Kinase by A1 Adenosine Receptor Activation. Biochem. Pharmacol. 2000, 59; 477-483.
- Sinclair, C.J.D. and J.D. Geiger. Caffeine Use in Sport: A Pharmacological Review. J. Sports Med. Phys. Fitness 2000, 40; 71-79.
- Mayne, M.B., C.P. Holden, A. Nath and J.D. Geiger. Release of Calcium from IP3, Receptor-Regulated Stores by HIV-1 Tat Regulates TNF-a Production in Human Macrophages. J. Immunol. 2000, 164; 6538-6542.
- S.L. Chan, M.B. Mayne, C.P. Holden, J.D. Geiger, and M.P. Mattson. Presenilin-1 Mutations Increase Levels of Ryanodine Receptors and Calcium Release in PC12 Cells and Cortical Neurons. J. Biol. Chem. 2000, 275; 18195-18200.
- Parkinson, F.E., Y.W. Zhang, P.N. Shepel, S.C. Greenway, J. Peeling, J.D. Geiger. Effects of Nitrobenzylthioinosine on Neuronal Injury, Adenosine Levels and Adenosine Receptor Activity in Rat Forebrain Ischemia. J. Neurochem. 2000, 75; 795-802.
- Mackiewicz, M., E.V. Nikonova, C.C. Bell, R.J. Galante, L. Zhang, J.D. Geiger and A.I. Pack. Activity of Adenosine Deaminase in the Sleep Regulatory Areas of the Rat CNS. Brain Research 2000, 80; 252-255.
- Mackiewicz, M., J.D. Geiger, A.I. Pack. Simultaneous Assessment of Ecto- and Cytosolic-5'-Nucleotidase Activities in Brain Micropunches. J. Neurosci. Methods. 2000, 104; 9-18.
- Sullivan, P.G/J.D. Geiger, M.P. Mattson, S.W. Scheff. Dietary Supplement Creatine Protects Against Traumatic Brain Injury. Ann. Neurol. 2000, 48; 723-729.
Chester Fritz Distinguished Professor
Interim Chair, Department of Anatomy and Cell Biology
Chair, Department of Pharmacology, Physiology and Therapeutics
E-Mail Address: email@example.com